Custom DNA Oligo Synthesis
modified oligonucleotides in scales adjusted to your specific needs.
Standard Custom Oligo Synthesis
| Synthesis Scale | Base Price | Column Purification | HPLC Purification | PAGE Purification |
| 50 nmole | $ 0.39/base | $ 12.00 | $ 30.00 | $ 45.00 |
| 100 nmole | $ 0.49/base | $ 12.00 | $ 30.00 | $ 55.00 |
| 200 nmole | $ 0.70/base | $ 12.00 | $ 30.00 | $ 65.00 |
| 1 µmole | $ 1.75/base | $ 40.00 | $ 60.00 | $ 100.00 |
| 15 µmole | $ 10.00/base | $ 120.00 | $ 200.00 | $ 1,000.00 |
| 50 µmole | $ 25.00/base | $ 250.00 | $ 500.00 | $ 2,000.00 |
- Desalt service for all standard oligo synthesis is free of charge.
- All standard custom oligos can be delivered in either lyophilized form or hydrated in a specific concerntration
| Purification | Application | Shipping |
| Desalted | PCR, DNA Sequencing | 24 hours |
| Column (OPC) | Subcloning, Kinase Labeling | 48 hours |
| HPLC | Antisense, Dianostic | 48 hours |
| PAGE | Site Mutagenesis, Gene Synthesis | 72 hours |
- This shipping schedule applies to most orders up to 1 µmole scale and receive before 11am.
- Large scale oligos order may take 3-7 working days depending upon length, modifications and purification.
| Synthesis Scale | Desalted | Column Purified(OPC) | HPLC | PAGE |
| 50 nmole | 5 OD | 5 OD | 2 OD | 2 OD |
| 100 nmole | 7 OD | 7 OD | 4 OD | 3 OD |
| 200 nmole | 15 OD | 15 OD | 7 OD | 5 OD |
| 1 µmole | 30 OD | 30 OD | 15 OD | 10 OD |
Non-standard Custom Oligo Synthesis
| Synthesis Scale | Base Price | Column Purification | HPLC Purification | PAGE Purification |
| 200 nmole | $ 2.00/base | $ 12.00 | $ 30.00 | $ 65.00 |
| 1 µmole | $ 2.50/base | $ 40.00 | $ 60.00 | $ 100.00 |
| 15 µm | $ 14.00/base | $ 120.00 | $ 200.00 | $ 1,000.00 |
| 50 µm | $ 30.00/base | $ 250.00 | $ 500.00 | $ 2,000.00 |
Oligonucleotides Modifications
Syngen specializes in modified chemistries.
Our staff of chemist can reproducibly deliver quality modified oligonucleotide products.
| Modifications | Synthesis Scale | |||
| up to 200 nmole | 1 umole | |||
| 3' Mod | 5' Mod | 3' Mod | 5' Mod | |
| Biotin | $ 18.00 | $ 30.00 | $ 45.00 | $ 80.00 |
| Fluorescein | $ 20.00 | $ 40.00 | $ 50.00 | $ 100.00 |
| Amino | $ 15.00 | $ 25.00 | $ 40.00 | $ 70.00 |
| Thiol | $ 15.00 | $ 25.00 | $ 40.00 | $ 70.00 |
| Phosphorylation | $ 15.00 | $ 25.00 | $ 40.00 | $ 70.00 |
| Dabcyl | $ 30.00 | $ 50.00 | $ 80.00 | $ 120.00 |
| Tamra | $ 50.00 | $ 60.00 | $ 90.00 | $ 120.00 |
| Cy3 | $ 50.00 | $ 80.00 | $ 100.00 | $ 150.00 |
| Cy5 | $ 50.00 | $ 80.00 | $ 100.00 | $ 150.00 |
| HEX | $ 35.00 | $ 85.00 | Inquire | $ 125.00 |
| FAM | $ 35.00 | $ 85.00 | Inquire | $ 125.00 |
| TET | $ 35.00 | $ 85.00 | Inquire | $ 125.00 |
| Base Name | Scale | Price per Addition |
| DMT-dI | 100 nmole | $ 10.00 |
| DMT-dU | 100 nmole | $ 10.00 |
| DMT-5-Br-dU | 100 nmole | $ 15.00 |
| DMT-5-Br-dC | 100 nmole | $ 15.00 |
| DMT-5-Me-dC | 100 nmole | $ 15.00 |
| Scale of Synthesis | Purification | Yield | Price |
| 50 nmole | HPLC | 5,000 picomoles | $ 200.00 |
| 100 nmole | HPLC | 9,000 picomoles | $ 250.00 |
| 200 nmole | HPLC/PAGE | 15,000 picomoles | $ 300.00 |
| 1 µmole | HPLC/PAGE | 60,000 picomoles | $ 400.00 |
| Choice of 5' Reporters and 3' Quenchers | |||
| 5' Reporter | 3' Quencher | ||
| 6-FAM | TAMRA | ||
| HEX | Black Hole Quencher 0® (BHQ-0) | ||
| TET | Black Hold Quencher 1® (BHQ-1) | ||
| TAMRA | Black Hole Quencher 2® (BHQ-2) | ||
| Cy-3 | Dabcyl | ||
| Cy-5 | TQ™1 (replacement for BHQ-0®) | ||
| TQ™2 (replacement for BHQ-1®) | |||
| TQ™3 (replacement for BHQ-2®) | |||
"Black Hold Quencher", "BHQ-0", "BHQ-1", "BHQ-2" are registered trademarks of Biosearch Technologies, Novato, CA.
"TQ1", "TQ2", "TQ3" are registered trademarks of ABD Bioquest, Inc. Sunnyvale, CA.
For more information, please Email us: info@syngendna.com
Or call us at 1-650-637-0130.